Ontology highlight
ABSTRACT:
INSTRUMENT(S): Synapt MS
ORGANISM(S): Paracoccidioides Lutzii (strain Atcc Mya-826 / Pb01) (paracoccidioides Brasiliensis)
SUBMITTER: Alexandre Bailao
LAB HEAD: Alexandre Melo Bailao
PROVIDER: PXD002285 | Pride | 2015-10-02
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
RAW_MSe_Argentil_Pb01_R1.rar | Other | |||
RAW_MSe_Control_Pb01_R1.rar | Other | |||
RAW_MSe_Control_Pb01_R2.rar | Other | |||
RAW_MSe_Control_Pb01_R3.rar | Other | |||
Raw_MSe_Argentil_Pb01_R2.rar | Other |
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Frontiers in microbiology 20150618
The dimorphic fungi Paracoccidioides spp. are the etiological agents of paracoccidioidomycosis (PCM), a mycosis of high incidence in Brazil. The toxicity of drug treatment and the emergence of resistant organisms have led to research for new candidates for drugs. In this study, we demonstrate that the natural product argentilactone was not cytotoxic or genotoxic to MRC5 cells at the IC50 concentration to the fungus. We also verified the proteomic profile of Paracoccidioides lutzii after incubati ...[more]