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PTSD mouse amygdala proteome

ABSTRACT: Posttraumatic stress disorder (PTSD) is a prevalent psychiatric disorder. Several studies have attempted to characterize molecular alterations associated with PTSD, but most findings were limited to the investigation of specific cellular markers in the periphery or defined brain regions. In the current study, we aimed to unravel affected molecular pathways/mechanisms in the fear circuitry associated with PTSD. We interrogated a foot shock induced-PTSD mouse model by integrating proteomics and metabolomics profiling data. Alterations at the proteome level were analyzed using in vivo 15N metabolic labeling combined with mass spectrometry in prelimbic cortex (PrL), anterior cingulate cortex (ACC), basolateral amygdala (BLA), central nucleus of amygdala (CeA) and CA1 of hippocampus between shocked and non-shocked (control) mice, with and without fluoxetine treatment.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

SUBMITTER: Chi-Ya Kao

LAB HEAD: Christoph W Turck

PROVIDER: PXD002288 | Pride | 2022-02-28

REPOSITORIES: Pride

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			Action	DRS
	cyk_20120323_BLA_control_N15_cyto_01.RAW	Raw
	cyk_20120323_BLA_control_N15_cyto_01.srf	Other
	cyk_20120323_BLA_control_N15_cyto_02.RAW	Raw
	cyk_20120323_BLA_control_N15_cyto_02.srf	Other
	cyk_20120323_BLA_control_N15_cyto_03.RAW	Raw

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