Ontology highlight
ABSTRACT:
INSTRUMENT(S): TripleTOF 5600
ORGANISM(S): Rattus Norvegicus (rat)
TISSUE(S): Heart
SUBMITTER: Sandra Anjo
LAB HEAD: Bruno Manadas
PROVIDER: PXD002331 | Pride | 2015-09-09
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
ID146_IP_Cx43_I_IDA_01.wiff | Wiff | |||
ID146_IP_Cx43_I_IDA_01.wiff.scan | Wiff | |||
ID146_IP_Cx43_I_IDA_02.wiff | Wiff | |||
ID146_IP_Cx43_I_IDA_02.wiff.scan | Wiff | |||
ID146_IP_Cx43_I_R_IDA_01.wiff | Wiff |
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Martins-Marques Tania T Anjo Sandra Isabel SI Pereira Paulo P Manadas Bruno B Girão Henrique H
Molecular & cellular proteomics : MCP 20150827 11
The coordinated and synchronized cardiac muscle contraction relies on an efficient gap junction-mediated intercellular communication (GJIC) between cardiomyocytes, which involves the rapid anisotropic impulse propagation through connexin (Cx)-containing channels, namely of Cx43, the most abundant Cx in the heart. Expectedly, disturbing mechanisms that affect channel activity, localization and turnover of Cx43 have been implicated in several cardiomyopathies, such as myocardial ischemia. Besides ...[more]