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Lysine acetyltransfer supports platelet function

ABSTRACT: Identification of lysine acetylated proteins from washed, human platelets.

INSTRUMENT(S): Orbitrap Fusion ETD

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Platelet, Platelet

DISEASE(S): Wounds And Injuries

SUBMITTER: Joseph Aslan

LAB HEAD: Owen J. T. McCarty

PROVIDER: PXD002332 | Pride | 2015-08-12

REPOSITORIES: pride

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			Action	DRS
	Combined_acetylated_carbamylated_search.msf	Msf
	MCC1487_20ACN_20141119_OT.raw	Raw
	MCC1487_24ACN_20141119_OT.raw	Raw
	MCC1487_28ACN_20141119_OT.raw	Raw
	MCC1487_40ACN_20141119_OT.raw	Raw

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Publications

Lysine acetyltransfer supports platelet function.

Aslan J E JE Rigg R A RA Nowak M S MS Loren C P CP Baker-Groberg S M SM Pang J J David L L LL McCarty O J T OJ

Journal of thrombosis and haemostasis : JTH 20150829 10

<h4>Background and objectives</h4>The reversible acetylation of protein lysine ε-amino groups, catalyzed by lysine acetyltransferases and deacetylases, serves as a molecular switch in the orchestration of diverse cellular activities. Here, we aimed to investigate the role of lysine acetyltransfer in platelet function.<h4>Methods and results</h4>Proteomics methods identified 552 acetyllysine (acK) modifications on 273 platelet proteins that serve as candidate substrates for lysine acetyltransfera ...[more]

PMID: 26256950

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