Dataset Information

Mouse liver LC-MS/MS - The influence of AICAR - direct activator of AMP-activated protein kinase (AMPK) - on liver proteome in apoE-knockout mice

ABSTRACT: Shotgun LC-MS/MS on mitochondrial and cytosolic fraction of the liver of apoE-knockout mice

INSTRUMENT(S): Velos Plus

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Hepatocyte, Liver

DISEASE(S): Fatty Liver Disease

SUBMITTER: Maciej Suski

LAB HEAD: Ryszard Korbut

PROVIDER: PXD002615 | Pride | 2017-05-02

REPOSITORIES: Pride

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The influence of AICAR - direct activator of AMP-activated protein kinase (AMPK) - on liver proteome in apoE-knockout mice.

Suski Maciej M Wiśniewska Anna A Stachowicz Aneta A Olszanecki Rafał R Kuś Katarzyna K Białas Magdalena M Madej Józef J Korbut Ryszard R

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20170426

There is a growing body of evidence that altered functioning of apoE may aggravate cellular energy homeostasis and stress response, leading to oxidative stress, mitochondrial dysfunction, endoplasmic reticulum (ER) stress and inflammation, leading to hypercholesterolemia, dyslipidemia, liver steatosis and neurodegeneration. One of the key cellular responses to mitochondria and ER-stress related processes and cellular energy imbalance is AMP-activated protein kinase (AMPK), considered as a cellul ...[more]

PMID: 28455001

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			Action	DRS
	aicar.mzML	Mzml
	aicar.tandem.pep.xml	Pepxml
	aicar2.mzML	Mzml
	aicar2.tandem.pep.xml	Pepxml
	aicar2_step1.mzML	Mzml