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Prediction of Mortality In Acute Respiratory Distress Syndrome

ABSTRACT: Acute Respiratory Distress Syndrome (ARDS) continues to have a high mortality. The objective of this study is to understand the differences in disease biology between survivors and non-survivors by characterizing BALF protein expression profiles in individual ARDS subjects.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

DISEASE(S): Adult Respiratory Distress Syndrome

SUBMITTER: Kevin Viken

LAB HEAD: Maneesh Bhargava

PROVIDER: PXD002672 | Pride | 2018-10-24

REPOSITORIES: Pride

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			Action	DRS
	ARDS1140801PeptideReportHighControl.txt	Txt
	ARDS1140801ProteinReportHighControl.txt	Txt
	ARDS2140801PeptideReportHightControl.txt	Txt
	ARDS2140801ProteinReportHighControl.txt	Txt
	ARDS3140801PeptideReportHighControl.txt	Txt

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Publications

Bronchoalveolar Lavage Fluid Protein Expression in Acute Respiratory Distress Syndrome Provides Insights into Pathways Activated in Subjects with Different Outcomes.

Bhargava Maneesh M Viken Kevin K Wang Qi Q Jagtap Pratik P Bitterman Peter P Ingbar David D Wendt Chris C

Scientific reports 20170807 1

Acute respiratory distress syndrome (ARDS) is associated with high mortality. We sought to identify biological pathways in ARDS that differentiate survivors from non-survivors. We studied bronchoalveolar lavage fluid (BALF) from 36 patients with ARDS (20 survivors, 16 non-survivors). Each sample, obtained within seven days of ARDS onset, was depleted of high abundance proteins and labeled for iTRAQ LC-MS/MS separately. Protein identification and relative quantification was performed employing a ...[more]

PMID: 28785034

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