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A Biomarker Panel for Chronic Graft-versus-Host Disease

ABSTRACT: Using a quantitative proteomics approach, we compared pooled plasma samples from 35 patients with cGVHD obtained at a median of 103 days post-HCT and 18 patients without cGVHD obtained at matched timepoints to identify biomarkers for cGVHD.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

SUBMITTER: Qing Zhang

LAB HEAD: Sophie Paczesny

PROVIDER: PXD002762 | Pride | 2016-05-27

REPOSITORIES: Pride

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			Action	DRS
	SP032714_051614_iTRAQ_SCXall_01.msf	Msf
	SP032714_051614_iTRAQ_SCXall_02.msf	Msf
	SP032714_051614_iTRAQ_SCXall_03.msf	Msf
	SP032714_051614_iTRAQ_frac01_01.raw	Raw
	SP032714_051614_iTRAQ_frac01_02.raw	Raw

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Biomarker Panel for Chronic Graft-Versus-Host Disease.

Yu Jeffrey J Storer Barry E BE Kushekhar Kushi K Abu Zaid Mohammad M Zhang Qing Q Gafken Philip R PR Ogata Yuko Y Martin Paul J PJ Flowers Mary E ME Hansen John A JA Arora Mukta M Cutler Corey C Jagasia Madan M Pidala Joseph J Hamilton Betty K BK Chen George L GL Pusic Iskra I Lee Stephanie J SJ Paczesny Sophie S

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20160523 22

<h4>Purpose</h4>To identify diagnostic and prognostic markers of chronic graft-versus-host disease (cGVHD), the major cause of morbidity and mortality after allogeneic hematopoietic cell transplantation (HCT).<h4>Patients and methods</h4>Using a quantitative proteomics approach, we compared pooled plasma samples obtained at matched time points after HCT (median, 103 days) from 35 patients with cGVHD and 18 without cGVHD (data are available via ProteomeXchange with identifier PXD002762). Of 105 p ...[more]

PMID: 27217465

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