Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA227547PRJNA198734PRJNA227776PRJNA227774
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): B Cell, Embryonic Stem Cell
SUBMITTER: Michael Wierer
LAB HEAD: Matthias Mann
PROVIDER: PXD002769 | Pride | 2016-02-24
REPOSITORIES: Pride
Items per page: 1 - 5 of 14 |
Nature 20131215 7487
CCAAT/enhancer binding protein-α (C/EBPα) induces transdifferentiation of B cells into macrophages at high efficiencies and enhances reprogramming into induced pluripotent stem (iPS) cells when co-expressed with the transcription factors Oct4 (Pou5f1), Sox2, Klf4 and Myc (hereafter called OSKM). However, how C/EBPα accomplishes these effects is unclear. Here we find that in mouse primary B cells transient C/EBPα expression followed by OSKM activation induces a 100-fold increase in iPS cell repro ...[more]