Proteomics,Multiomics

Dataset Information

0

SCOPE 4 proteomics - Dual targeting of p53 and c-MYC selectively eliminates leukaemic stem cells


ABSTRACT: BaF3 were transfected with Jak2 V617F, Jak2 K539L or Mpl W515L, shotgun proteomic analysis with iTRAQ was performed

OTHER RELATED OMICS DATASETS IN: PRJNA112367PRJNA132313PRJNA208363PRJNA96045

INSTRUMENT(S): QSTAR

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): B Cell, Blood

DISEASE(S): Acute Leukemia

SUBMITTER: Andrew Williamson  

LAB HEAD: Prof. Tony Whetton

PROVIDER: PXD002782 | Pride | 2016-05-26

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
012111_AP_Scope4.4_Cyto_17.mzML Mzml
012111_AP_Scope4.4_Cyto_17.wiff Wiff
012111_AP_Scope4.4_Cyto_17.wiff.scan Wiff
012111_AP_Scope4.4_Cyto_18.mzML Mzml
012111_AP_Scope4.4_Cyto_18.wiff Wiff
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Publications


Chronic myeloid leukaemia (CML) arises after transformation of a haemopoietic stem cell (HSC) by the protein-tyrosine kinase BCR-ABL. Direct inhibition of BCR-ABL kinase has revolutionized disease management, but fails to eradicate leukaemic stem cells (LSCs), which maintain CML. LSCs are independent of BCR-ABL for survival, providing a rationale for identifying and targeting kinase-independent pathways. Here we show--using proteomics, transcriptomics and network analyses--that in human LSCs, ab  ...[more]

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