Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture, Mammary Gland Epithelial Cell
DISEASE(S): Breast Cancer
SUBMITTER: Alex von kriegsheim
LAB HEAD: Alex von Kriegsheim
PROVIDER: PXD003213 | Pride | 2016-12-23
REPOSITORIES: Pride
Action | DRS | |||
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150331_AK_MDAMB231.raw | Raw | |||
MaxQuantOutput.tar.gz | Other |
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Cell systems 20160127 1
Dynamic interactions between RhoA and Rac1, members of the Rho small GTPase family, play a vital role in the control of cell migration. Using predictive mathematical modeling, mass spectrometry-based quantitation of network components, and experimental validation in MDA-MB-231 mesenchymal breast cancer cells, we show that a network containing Rac1, RhoA, and PAK family kinases can produce bistable, switch-like responses to a graded PAK inhibition. Using a small chemical inhibitor of PAK, we demo ...[more]