Proteomics

Dataset Information

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N-glyco db/db mouse kidney - N-glycosylation proteome enrichment analysis in kidney reveals differences between diabetic mouse models


ABSTRACT: N-glycosylated proteome of db/db diabetic mice with diabetic nephropathy, additional effect of insulin on db/db mice.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Kidney

DISEASE(S): Diabetic Nephropathy

SUBMITTER: Leena Liljedahl  

LAB HEAD: Peter James

PROVIDER: PXD003349 | Pride | 2016-12-13

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
140218_LL_LiraI_A10_6Dil_01.RAW Raw
140218_LL_LiraI_A1_6Dil_01.RAW Raw
140218_LL_LiraI_A2_6Dil_01.RAW Raw
140218_LL_LiraI_A3_6Dil_01.RAW Raw
140218_LL_LiraI_A4_6Dil_01.RAW Raw
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Publications

N-glycosylation proteome enrichment analysis in kidney reveals differences between diabetic mouse models.

Liljedahl Leena L   Pedersen Maiken Højgaard MH   Norlin Jenny J   McGuire James N JN   James Peter P  

Clinical proteomics 20161015


<h4>Background</h4>Diabetic nephropathy (DN) is a late complication in both type 1 diabetes mellitus (T1DM) and T2DM. Already at an early stage of DN morphological changes occur at the cell surface and in the extracellular matrix where the majority of the proteins carry N-linked glycosylations. These glycosylated proteins are highly important in cell adhesion and cell-matrix processes but not much is known about how they change in DN or whether the distinct etiology of T1DM and T2DM could have a  ...[more]

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