Proteomics

Dataset Information

0

Malaria Palmitoyl Transferases


ABSTRACT: Proteomic Interactome of Plasmodium Falciparum DHHC

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Plasmodium Falciparum (isolate 3d7)

SUBMITTER: James Wright  

LAB HEAD: Jyoti Choudhary

PROVIDER: PXD003350 | Pride | 2020-01-21

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
CH_DHHC5_allbands_PlasmoDB26.msf Msf
CH_DHHC9_allbands_PlasmoDB26.msf Msf
OT25cm_CH_DHHC5-12.raw Raw
OT25cm_CH_DHHC5-3.raw Raw
OT25cm_CH_DHHC5-4.raw Raw
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Publications

Study of Plasmodium falciparum DHHC palmitoyl transferases identifies a role for PfDHHC9 in gametocytogenesis.

Tay Chwen L CL   Jones Matthew L ML   Hodson Nicola N   Theron Michel M   Choudhary Jyoti S JS   Rayner Julian C JC  

Cellular microbiology 20160503 11


Palmitoylation is the post-translational reversible addition of the acyl moiety, palmitate, to cysteine residues of proteins and is involved in regulating protein trafficking, localization, stability and function. The Aspartate-Histidine-Histidine-Cysteine (DHHC) protein family, named for their highly conserved DHHC signature motif, is thought to be responsible for catalysing protein palmitoylation. Palmitoylation is widespread in all eukaryotes, including the malaria parasite, Plasmodium falcip  ...[more]

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