Dataset Information

Expression changes of proteins associated with the development of preeclampsia in maternal plasma: a case control study

ABSTRACT: Defective deep placentation, an abnormal transformation of the spiral arteries in the junctional zone of the myometrium, is known to cause significant obstetrical complications such as preeclampsia (PE), fetal growth restriction, and placental infarcts with fetal death. Serological biomarkers to predict and diagnose PE would help antenatal care and reduce the obstetrical complications. To discover biomarkers for prediction of PE, we first performed global proteome profiling of three pairs of maternal plasma samples obtained from the early second trimester pregnant women who subsequently developed PE and controls to identify proteins that were abundant in the patients. We further evaluated the expression changes of PE representing proteins in stored plasma samples of a cohort of subsequently developed PE and their matched controls by MRM assay. We identified both Complement C1s subcomponent (p-value = 0.041) and Protein AMBP (p-value = 0.043) were up-regulated in the cohort of PE plasma samples before manifestation of clinical disease. We propose that these proteins may be involved in the remodeling process of the spiral arteries even before the manifestation of PE. These proteins could be served as potential plasma biomarkers to predict pregnant women at increased risk of developing PE.

INSTRUMENT(S): LTQ

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

SUBMITTER: Byoung-Kyu Cho

LAB HEAD: Eugene C. Yi

PROVIDER: PXD003419 | Pride | 2018-07-05

REPOSITORIES: pride

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Dataset's files

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			Action	DRS
	1150-PE_Extreme_1pair_C_02frac_2nd.protXML	Other
	1151-PE_Extreme_1pair_D_02frac_1st.protXML	Other
	1152-PE_Extreme_1pair_D_02frac_2nd.protXML	Other
	1153-PE_Extreme_1pair_C_02frac_1st.protXML	Other
	1154-PE_Extreme_1pair_C_04frac_1st.protXML	Other

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Publications

Expression changes of proteins associated with the development of preeclampsia in maternal plasma: A case-control study.

Kim Sun Min SM Cho Byoung-Kyu BK Kang Min Jueng MJ Norwitz Errol R ER Lee Seung Mi SM Lee Joonho J Park Chan-Wook CW Kim Byoung Jae BJ Jun Jong Kwan JK Park Joong Shin JS Yi Eugene C EC

Proteomics 20160501 10

Defective deep placentation, involving abnormal transformation of the spiral arteries in the junctional zone of the myometrium, is known to cause significant obstetric complications, such as preeclampsia (PE), fetal growth restriction, and placental infarction leading to fetal death. Serological biomarkers to predict and diagnose PE would help antenatal care and reduce obstetric complications. To discover candidate PE biomarkers, we first performed global proteomic profiling of three pairs of pl ...[more]

PMID: 27001287

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