Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
DISEASE(S): Metastatic Melanoma
SUBMITTER: Boris Zybailov
LAB HEAD: Boris Zybaylov
PROVIDER: PXD003501 | Pride | 2016-07-07
REPOSITORIES: Pride
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G4peptides.pep.xml | Pepxml | |||
Zybaylov_102413_G4_01.raw | Raw | |||
Zybaylov_102413_G4_02.raw | Raw | |||
Zybaylov_102413_G4_03.raw | Raw | |||
Zybaylov_102413_G4_04.raw | Raw |
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Byrd Alicia K AK Zybailov Boris L BL Maddukuri Leena L Gao Jun J Marecki John C JC Jaiswal Mihir M Bell Matthew R MR Griffin Wezley C WC Reed Megan R MR Chib Shubeena S Mackintosh Samuel G SG MacNicol Angus M AM Baldini Giulia G Eoff Robert L RL Raney Kevin D KD
The Journal of biological chemistry 20160701 34
Cells engage numerous signaling pathways in response to oxidative stress that together repair macromolecular damage or direct the cell toward apoptosis. As a result of DNA damage, mitochondrial DNA or nuclear DNA has been shown to enter the cytoplasm where it binds to "DNA sensors," which in turn initiate signaling cascades. Here we report data that support a novel signaling pathway in response to oxidative stress mediated by specific guanine-rich sequences that can fold into G-quadruplex DNA (G ...[more]