Proteomics

Dataset Information

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G4 Quadruplex Binding Proteins


ABSTRACT: In this study we discover proteins that bind to G4 quadruplex DNA structure. We use modified c-myc quadruplex as a bait, and compare it to the control bait - T15 oligo. We use spectral counts and G-test to determine significant binders. T15 and G4 datafiles are uploaded

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

DISEASE(S): Metastatic Melanoma

SUBMITTER: Boris Zybailov  

LAB HEAD: Boris Zybaylov

PROVIDER: PXD003501 | Pride | 2016-07-07

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
G4peptides.pep.xml Pepxml
Zybaylov_102413_G4_01.raw Raw
Zybaylov_102413_G4_02.raw Raw
Zybaylov_102413_G4_03.raw Raw
Zybaylov_102413_G4_04.raw Raw
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Publications

Evidence That G-quadruplex DNA Accumulates in the Cytoplasm and Participates in Stress Granule Assembly in Response to Oxidative Stress.

Byrd Alicia K AK   Zybailov Boris L BL   Maddukuri Leena L   Gao Jun J   Marecki John C JC   Jaiswal Mihir M   Bell Matthew R MR   Griffin Wezley C WC   Reed Megan R MR   Chib Shubeena S   Mackintosh Samuel G SG   MacNicol Angus M AM   Baldini Giulia G   Eoff Robert L RL   Raney Kevin D KD  

The Journal of biological chemistry 20160701 34


Cells engage numerous signaling pathways in response to oxidative stress that together repair macromolecular damage or direct the cell toward apoptosis. As a result of DNA damage, mitochondrial DNA or nuclear DNA has been shown to enter the cytoplasm where it binds to "DNA sensors," which in turn initiate signaling cascades. Here we report data that support a novel signaling pathway in response to oxidative stress mediated by specific guanine-rich sequences that can fold into G-quadruplex DNA (G  ...[more]

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