Proteomics

Dataset Information

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Human plasma peptidomics - Identification and quantification of plasma free salusin-β, an endogenous parasympathomimetic peptide


ABSTRACT: We have improved our ultrahigh-yield method, which we named “differential solubilization" (J Proteome Res 9, 2010, 1694-1705), to extract and analyse low-molecular-weight plasma peptides, and initiated a large-scale sequencing of circulating native peptides at concentrations as low as the picomolar level using less than 200 μl of human plasma.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

SUBMITTER: Yoshio Kodera  

LAB HEAD: Yoshio Kodera

PROVIDER: PXD003533 | Pride | 2018-10-26

REPOSITORIES: pride

Dataset's files

Source:
Action DRS
Data1M.mgf Mgf
Data1M.mzid Mzid
Data1P.mzid Mzid
Data2M.mgf Mgf
Data2M.mzid Mzid
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Publications

Identification and quantification of plasma free salusin-β, an endogenous parasympathomimetic peptide.

Fujimoto Kazumi K   Hayashi Akinori A   Kodera Yoshio Y   Saito Tatsuya T   Toki Takuya T   Ogawa Akifumi A   Kamata Yuji Y   Takano Koji K   Katakami Hideki H   Shichiri Masayoshi M  

Scientific reports 20170815 1


Salusin-β is an endogenous parasympathomimetic proatherosclerotic peptide. Salusin-β was initially predicted from bioinformatic analyses and later immunologically detected in human biofluids. However, elucidation of salusin-β bioactivity has faced enormous challenges because of its unique physicochemical characteristics that cause it to strongly adhere to laboratory apparatus materials. In the strictest sense, the discovery of bioactive peptides is not complete until their exact native sequences  ...[more]

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