Dataset Information

Human blastoceol fluid LC-MSMS

ABSTRACT: The objective of this prospective study is to employ proteomic techniques and bioinformatic tools to enlight differences at the protein level in blastocoel fluid of aged and younger woman.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Embryo

SUBMITTER: gabriella tedeschi

LAB HEAD: Gabriella Tedeschi

PROVIDER: PXD003535 | Pride | 2017-01-19

REPOSITORIES: Pride

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Publications

Proteomic profile of maternal-aged blastocoel fluid suggests a novel role for ubiquitin system in blastocyst quality.

Tedeschi Gabriella G Albani Elena E Borroni Elena Monica EM Parini Valentina V Brucculeri Anna Maria AM Maffioli Elisa E Negri Armando A Nonnis Simona S Maccarrone Mauro M Levi-Setti Paolo Emanuele PE

Journal of assisted reproduction and genetics 20161206 2

<h4>Purpose</h4>The etiology of maternal aging, a common cause of female factor infertility and a rate-limiting step in vitro fertilization (IVF) success, remains still unclear. Proteomic changes responsible for the impaired successful pregnancy outcome after IVF with aged blastocysts have not been yet evaluated. The objective of this prospective study was to employ proteomic techniques and bioinformatic tools to enlight differences at the protein level in blastocoel fluid of aged and younger wo ...[more]

PMID: 27924460

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