Dataset Information

Systems toxicological assessment of the mentholated Tobacco Heating System 2.2 product revealed reduced cellular and molecular exposure effects compared to cigarette smoke [quantitative proteomics of lung tissue]

ABSTRACT: Aiming to reduce smoking-related health risks, potential reduced risk products (pRRPs) are being developed. The Tobacco Heating System (THS) 2.2 is a recently developed pRRP, which utilizes the heat-not-burn principle. In this study, systems toxicology approaches were engaged to assess the respiratory effects of a mentholated version of THS2.2 (THS2.2M) in a 90-day rat inhalation study (OECD test guideline 413). This is the quantitative proteomics data set for rat lung tissue. As described in the sample processing protocol, two different iTRAQ sets were defined and analyzed separately. See i_Rat-THS2.2M-TG413_protItraq_LeftLung.xlsx for sample annotations and file mappings.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Lung

SUBMITTER: Bjoern Titz

LAB HEAD: Julia Hoeng

PROVIDER: PXD003580 | Pride | 2016-12-12

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	20150119_176500__CNU_05_OECD_P1M_LL_9042_Set1_sensitive.raw	Raw
	20150119_176500__CNU_06_OECD_P1M_LL_9042_Set6_sensitive.raw	Raw
	20150119_176500__CNU_07_OECD_P1M_LL_9042_Set2_fast.raw	Raw
	20150119_176500__CNU_08_OECD_P1M_LL_9042_Set3_sensitive.raw	Raw
	20150119_176500__CNU_09_OECD_P1M_LL_9042_Set3_fast.raw	Raw

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Publications

Evaluation of the Tobacco Heating System 2.2. Part 7: Systems toxicological assessment of a mentholated version revealed reduced cellular and molecular exposure effects compared with mentholated and non-mentholated cigarette smoke.

Kogel Ulrike U Titz Bjoern B Schlage Walter K WK Nury Catherine C Martin Florian F Oviedo Alberto A Lebrun Stefan S Elamin Ashraf A Guedj Emmanuel E Trivedi Keyur K Ivanov Nikolai V NV Vanscheeuwijck Patrick P Peitsch Manuel C MC Hoeng Julia J

Regulatory toxicology and pharmacology : RTP 20161104

Modified risk tobacco products (MRTPs) are being developed with the aim of reducing smoking-related health risks. The Tobacco Heating System 2.2 (THS2.2) is a candidate MRTP that uses the heat-not-burn principle. Here, systems toxicology approaches were engaged to assess the respiratory effects of mentholated THS2.2 (THS2.2M) in a 90-day rat inhalation study (OECD test guideline 413). The standard endpoints were complemented by transcriptomics and quantitative proteomics analyses of respiratory ...[more]

PMID: 27818347

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