Dataset Information

Serum proteomics reveals a sexually dimorphic effect of vitamin D status correction on proteins of the blood coagulation pathway among overweight adults

ABSTRACT: Background: An important feature to vitamin D physiology is its gender dependence. The aim of this study was to examine whether vitamin D exerts a sexually dimorphic effect on the blood coagulation pathway among adults with overweight. Methods: This study compared the serum proteomic profiles of age and BMI-matched males (n=26) and pre-menopausal females (n=24) with overweight that attained vitamin D sufficiency after a 12-month intervention. Unprocessed serum was subjected to depletion-free, quantitative proteomic analysis using our previously published methodology. Results. A total of 1,841 proteins were profiled (p < 0.05). The analysed proteins vitamin-K dependent protein C, von Willebrand factor, fibrinogen gamma chain and multimerin-1 were ELISA validated to be differentially affected between genders by vitamin D status improvement. Conclusions: Vitamin D optimization exhibits a sexually dimorphic effect on the blood coagulation pathway among adults with overweight. This gender specific vitamin D effect should be taken into consideration in the design and interpretation of vitamin D observational and intervention studies.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Serum

SUBMITTER: Antigoni Manousopoulou

LAB HEAD: Spiros D. Garbis

PROVIDER: PXD003663 | Pride | 2016-10-13

REPOSITORIES: Pride

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			Action	DRS
	23NOV13_KSU_projB_new_seg04_23.raw	Raw
	23NOV13_KSU_projB_new_seg04_24.raw	Raw
	23NOV13_KSU_projB_new_seg04_25.raw	Raw
	23NOV13_KSU_projB_new_seg04_25_5.raw	Raw
	23NOV13_KSU_projB_new_seg04_26-rep.raw	Raw

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Sex-specific vitamin D effects on blood coagulation among overweight adults.

Al-Daghri Nasser M NM Alokail Majed S MS Manousopoulou Antigoni A Heinson Ashley A Al-Attas Omar O Al-Saleh Yousef Y Sabico Shaun S Yakout Sobhy S Woelk Christopher H CH Chrousos George P GP Garbis Spiros D SD

European journal of clinical investigation 20161101 12

<h4>Background</h4>Overweight adults are at increased risk for cardiovascular disease and vitamin D deficiency, whereas an important feature to vitamin D physiology is its sex dependence. The aim of this study was to examine whether vitamin D status improvement exerts a sexually dimorphic effect on serum proteins associated with cardiovascular risk among overweight adults.<h4>Materials and methods</h4>Unprocessed serum from age- and BMI-matched men (n = 26) and premenopausal women (n = 24) with ...[more]

PMID: 27727459

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