Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA314489
INSTRUMENT(S): LTQ Orbitrap, Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Primary Cell
SUBMITTER: Guillaume Arras
LAB HEAD: Damarys Loew
PROVIDER: PXD003670 | Pride | 2017-09-18
REPOSITORIES: Pride
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C2337FD-01.msf | Msf | |||
C2337FD.raw | Raw | |||
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Nature communications 20171013 1
At the stage of carcinoma in situ, the basement membrane (BM) segregates tumor cells from the stroma. This barrier must be breached to allow dissemination of the tumor cells to adjacent tissues. Cancer cells can perforate the BM using proteolysis; however, whether stromal cells play a role in this process remains unknown. Here we show that an abundant stromal cell population, cancer-associated fibroblasts (CAFs), promote cancer cell invasion through the BM. CAFs facilitate the breaching of the B ...[more]