Proteomics

Dataset Information

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CLK IP-MS - CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor

ABSTRACT: CLK kinase was immunoprecipitated using differential tagging of the N- and C-terminus

INSTRUMENT(S): Orbitrap Fusion ETD

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Christopher Hughes  

LAB HEAD: Gregg Morin

PROVIDER: PXD003839 | Pride | 2017-03-14

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
ch_17Sept2015_Esther_IP_TMT6_1_PSMs.txt Txt
ch_17Sept2015_Esther_IP_TMT6_1_Proteins.txt Txt
ch_17Sept2015_Esther_IP_TMT6_1_trep1.raw Raw
ch_17Sept2015_Esther_IP_TMT6_1_trep2.raw Raw
ch_17Sept2015_Esther_IP_TMT6_1_trep3.raw Raw
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Publications

CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor.

Funnell Tyler T   Tasaki Shinya S   Oloumi Arusha A   Araki Shinsuke S   Kong Esther E   Yap Damian D   Nakayama Yusuke Y   Hughes Christopher S CS   Cheng S-W Grace SG   Tozaki Hirokazu H   Iwatani Misa M   Sasaki Satoshi S   Ohashi Tomohiro T   Miyazaki Tohru T   Morishita Nao N   Morishita Daisuke D   Ogasawara-Shimizu Mari M   Ohori Momoko M   Nakao Shoichi S   Karashima Masatoshi M   Sano Masaya M   Murai Aiko A   Nomura Toshiyuki T   Uchiyama Noriko N   Kawamoto Tomohiro T   Hara Ryujiro R   Nakanishi Osamu O   Shumansky Karey K   Rosner Jamie J   Wan Adrian A   McKinney Steven S   Morin Gregg B GB   Nakanishi Atsushi A   Shah Sohrab S   Toyoshiba Hiroyoshi H   Aparicio Samuel S  

Nature communications 20170223 1

CDC-like kinase phosphorylation of serine/arginine-rich proteins is central to RNA splicing reactions. Yet, the genomic network of CDC-like kinase-dependent RNA processing events remains poorly defined. Here, we explore the connectivity of genomic CDC-like kinase splicing functions by applying graduated, short-exposure, pharmacological CDC-like kinase inhibition using a novel small molecule (T3) with very high potency, selectivity, and cell-based stability. Using RNA-Seq, we define CDC-like kina  ...[more]

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