Proteomics

Dataset Information

0

Mouse Smooth muscle cell secretome with Anti-miR / pre-miR treatment


ABSTRACT: Overexpression and inhibition of miR-29 (pre-miR and anti-miR to miR-29b) in murine aortic smooth muscle cells, analysis of their secretome (conditioned media after serum starvation), n=3 for all four groups (pre-miR control, pre-miR-29b, anti-miR control, anti-miR-29b).

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Aortic Smooth Muscle, Aortic Smooth Muscle Cell

DISEASE(S): Aortic Atherosclerosis

SUBMITTER: Xiaoke Yin  

LAB HEAD: Manuel Mayr

PROVIDER: PXD003938 | Pride | 2016-05-06

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
A29_1_01.RAW Raw
A29_1_01.dat-pride.pride.mgf.gz Mgf
A29_1_01.dat-pride.pride.mztab.gz Mztab
A29_1_01.dat-pride.xml.gz Xml
A29_1_02.RAW Raw
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Publications


Abnormal remodeling of atherosclerotic plaques can lead to rupture, acute myocardial infarction, and death. Enhancement of plaque extracellular matrix (ECM) may improve plaque morphology and stabilize lesions. Here, we demonstrate that chronic administration of LNA-miR-29 into an atherosclerotic mouse model improves indices of plaque morphology. This occurs due to upregulation of miR-29 target genes of the ECM (col1A and col3A) resulting in reduced lesion size, enhanced fibrous cap thickness, an  ...[more]

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