Proteomics

Dataset Information

0

Data in support of Synthesis and deposition of basement membrane proteins by primary brain capillary endothelial cells in a murine model of the blood-brain barrier


ABSTRACT: The aim of the present study was to analyze four different in vitro models of the murine BBB for expression and possible secretion of major basement membrane proteins from murine BCECs (mBCECs). The mBCECs and pericytes were isolated from brains of adult C57BL/6 mice, and glial cells (mainly astrocytes and microglia) were prepared from cerebral cortices of newborn C57BL/6 mice. The mBCECs were grown as mono-culture, in co-culture with pericytes or mixed glial cells, or as a triple-culture with both pericytes and mixed glial cells.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

SUBMITTER: Allan Stensballe  

LAB HEAD: Allan Stensballe

PROVIDER: PXD003981 | Pride | 2016-08-03

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
MaxQuantOutput.zip Other
coculture03_01.raw Raw
coculture03_02.raw Raw
coculture03_03.raw Raw
coculture04_01.raw Raw
Items per page:
1 - 5 of 13
altmetric image

Publications

Synthesis and deposition of basement membrane proteins by primary brain capillary endothelial cells in a murine model of the blood-brain barrier.

Thomsen Maj Schneider MS   Birkelund Svend S   Burkhart Annette A   Stensballe Allan A   Moos Torben T  

Journal of neurochemistry 20160908 5


The brain vascular basement membrane is important for both blood-brain barrier (BBB) development, stability, and barrier integrity and the contribution hereto from brain capillary endothelial cells (BCECs), pericytes, and astrocytes of the BBB is probably significant. The aim of this study was to analyse four different in vitro models of the murine BBB for expression and possible secretion of major basement membrane proteins from murine BCECs (mBCECs). mBCECs, pericytes and glial cells (mainly a  ...[more]

Similar Datasets

2013-12-30 | E-GEOD-24915 | biostudies-arrayexpress
2013-12-30 | E-GEOD-24913 | biostudies-arrayexpress
| PRJNA944785 | ENA
2005-12-09 | GSE3767 | GEO
2013-03-25 | GSE41184 | GEO
2010-06-20 | E-GEOD-21139 | biostudies-arrayexpress
2017-01-01 | GSE54765 | GEO
2020-01-01 | GSE108726 | GEO
2024-03-13 | E-MTAB-13833 | biostudies-arrayexpress
2024-03-06 | E-MTAB-13841 | biostudies-arrayexpress