Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Arabidopsis Thaliana (mouse-ear Cress)
TISSUE(S): Cell In Vitro
DISEASE(S): Disease Free
SUBMITTER: Wolfgang Hoehenwarter
LAB HEAD: Wolfgang Hoehenwarter
PROVIDER: PXD004027 | Pride | 2017-06-14
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
MIN090316_IAA19_all.mgf | Mgf | |||
MIN090316_IAA19_all.pride.mgf.gz | Mgf | |||
MIN090316_IAA19_all.raw | Raw | |||
MIN090316_IAA19_all_F009115.mzid.gz | Mzid | |||
MIN090316_IAA19_all_F009115.pride.mztab.gz | Mztab |
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Winkler Martin M Niemeyer Michael M Hellmuth Antje A Janitza Philipp P Christ Gideon G Samodelov Sophia L SL Wilde Verona V Majovsky Petra P Trujillo Marco M Zurbriggen Matias D MD Hoehenwarter Wolfgang W Quint Marcel M Calderón Villalobos Luz Irina A LIA
Nature communications 20170607
Auxin is a small molecule morphogen that bridges SCF<sup>TIR1/AFB</sup>-AUX/IAA co-receptor interactions leading to ubiquitylation and proteasome-dependent degradation of AUX/IAA transcriptional repressors. Here, we systematically dissect auxin sensing by SCF<sup>TIR1</sup>-IAA6 and SCF<sup>TIR1</sup>-IAA19 co-receptor complexes, and assess IAA6/IAA19 ubiquitylation in vitro and IAA6/IAA19 degradation in vivo. We show that TIR1-IAA19 and TIR1-IAA6 have distinct auxin affinities that correlate wi ...[more]