Dataset Information

Quantitative proteomics of rat livers shows that unrestricted feeding and re-feeding after food restriction are stressful for cellular proteostasis

ABSTRACT: We used quantitative MS-based proteomic analysis of whole rat livers to study the molecular events associated with a food restriction regimen as compared with ad libitum food and animals re-fed after a restriction time.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Liver

SUBMITTER: Manfredo Quadroni

LAB HEAD: Pierre Goloubinoff

PROVIDER: PXD004068 | Pride | 2016-12-23

REPOSITORIES: Pride

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Quantitative proteomics of rat livers shows that unrestricted feeding is stressful for proteostasis with implications on life span.

Gat-Yablonski Galia G Finka Andrija A Pinto Galit G Quadroni Manfredo M Shtaif Biana B Goloubinoff Pierre P

Aging 20160801 8

Studies in young mammals on the molecular effects of food restriction leading to prolong adult life are scares. Here, we used high-throughput quantitative proteomic analysis of whole rat livers to address the molecular basis for growth arrest and the apparent life-prolonging phenotype of the food restriction regimen. Over 1800 common proteins were significantly quantified in livers of ad libitum, restriction- and re-fed rats, which summed up into 92% of the total protein mass of the cells. Compa ...[more]

PMID: 27508340

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