Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA320049
INSTRUMENT(S): LTQ
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Hela Cell
SUBMITTER: Yu Zhang
LAB HEAD: Yongfeng Shang
PROVIDER: PXD004271 | Pride | 2016-06-08
REPOSITORIES: Pride
Zhang Yu Y Zhang Di D Li Qian Q Liang Jing J Sun Luyang L Yi Xia X Chen Zhe Z Yan Ruorong R Xie Guojia G Li Wanjin W Liu Shumeng S Xu Bosen B Li Lei L Yang Jianguo J He Lin L Shang Yongfeng Y
Nature genetics 20160808 9
FOXA1 functions in epigenetic reprogramming and is described as a 'pioneer factor'. However, exactly how FOXA1 achieves these remarkable biological functions is not fully understood. Here we report that FOXA1 associates with DNA repair complexes and is required for genomic targeting of DNA polymerase β (POLB) in human cells. Genome-wide DNA methylomes demonstrate that the FOXA1 DNA repair complex is functionally linked to DNA demethylation in a lineage-specific fashion. Depletion of FOXA1 result ...[more]