Dataset Information

Glycoproteomics reveals the presence of decorin peptides with anti-myostatin activity in human atrial fibrillation

ABSTRACT: We analysed by proteomics the cardiac extraceelular matrix in human atrial fibrillation and disvovered the presence of extracellular matrix protein fragments that can regulate cardiac cell physiology

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Heart

DISEASE(S): Cardiovascular System Disease

SUBMITTER: Javier Barallobre-Barreiro

LAB HEAD: Manuel Mayr

PROVIDER: PXD004465 | Pride | 2016-09-29

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	F013939.dat-pride.pride.mgf.gz	Mgf
	F013939.dat-pride.pride.mztab.gz	Mztab
	F013939.dat-pride.xml.gz	Xml
	F013940.dat-pride.pride.mgf.gz	Mgf
	F013940.dat-pride.pride.mztab.gz	Mztab

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Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation.

Barallobre-Barreiro Javier J Gupta Shashi K SK Zoccarato Anna A Kitazume-Taneike Rika R Fava Marika M Yin Xiaoke X Werner Tessa T Hirt Marc N MN Zampetaki Anna A Viviano Alessandro A Chong Mei M Bern Marshall M Kourliouros Antonios A Domenech Nieves N Willeit Peter P Shah Ajay M AM Jahangiri Marjan M Schaefer Liliana L Fischer Jens W JW Iozzo Renato V RV Viner Rosa R Thum Thomas T Heineke Joerg J Kichler Antoine A Otsu Kinya K Mayr Manuel M

Circulation 20160824 11

<h4>Background</h4>Myocardial fibrosis is a feature of many cardiac diseases. We used proteomics to profile glycoproteins in the human cardiac extracellular matrix (ECM).<h4>Methods</h4>Atrial specimens were analyzed by mass spectrometry after extraction of ECM proteins and enrichment for glycoproteins or glycopeptides.<h4>Results</h4>ECM-related glycoproteins were identified in left and right atrial appendages from the same patients. Several known glycosylation sites were confirmed. In addition ...[more]

PMID: 27559042

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