Proteomics

Dataset Information

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Mapping and Quantification of Brain Protein O-GlcNAcylation in Alzheimer’s Disease

ABSTRACT: Comprehensive, quantitative proteomics analysis of protein O-GlcNAcylation in post-mortem human brains with and without Alzheimer’s using isobaric tandem mass tags labeling, chemoenzymatic photocleavage enrichment and liquid chromatography coupled to mass spectrometry.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cerebral Gray Matter

DISEASE(S): Alzheimer's Disease

SUBMITTER: Matthew Monroe  

LAB HEAD: Tao Liu

PROVIDER: PXD004510 | Pride | 2017-09-04

REPOSITORIES: pride

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Dataset's files

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Action DRS
AD_1_TMT_01_17Sep15_Samwise_15-08-22.mgf Mgf
AD_1_TMT_01_17Sep15_Samwise_15-08-22.pride.mgf.gz Mgf
AD_1_TMT_01_17Sep15_Samwise_15-08-22.raw Raw
AD_1_TMT_01_17Sep15_Samwise_15-08-22_ReporterIons_TMT.txt Txt
AD_1_TMT_01_17Sep15_Samwise_15-08-22_msgfplus.mzid.gz Mzid
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Publications

Quantitative proteomics identifies altered O-GlcNAcylation of structural, synaptic and memory-associated proteins in Alzheimer's disease.

Wang Sheng S   Yang Feng F   Petyuk Vladislav A VA   Shukla Anil K AK   Monroe Matthew E ME   Gritsenko Marina A MA   Rodland Karin D KD   Smith Richard D RD   Qian Wei-Jun WJ   Gong Cheng-Xin CX   Liu Tao T  

The Journal of pathology 20170728 1

Protein modification by O-linked β-N-acetylglucosamine (O-GlcNAc) is emerging as an important factor in the pathogenesis of sporadic Alzheimer's disease (AD); however, detailed molecular characterization of this important protein post-translational modification at the proteome level has been highly challenging, owing to its low stoichiometry and labile nature. Herein, we report the most comprehensive, quantitative proteomics analysis for protein O-GlcNAcylation in postmortem human brain tissues  ...[more]

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