Proteomics

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Serial co-immunoprecipitation to expand the protein interactome of the outer mitosomal membrane in Giardia lamblia

ABSTRACT: Giardia lamblia's outer mitosomal membrane protein repertoire was investigated using a series of co-immunoprecipitations which led to the discovery of novel associated components. This was assembled into a Giardia mitosomal protein interactome which expands beyond the organelle, reaching out to other subcellular compartments.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Giardia Lamblia Atcc 50803

TISSUE(S): Eukaryotic Cell, Cell Culture

DISEASE(S): Giardiasis

SUBMITTER: Carmen Faso  

LAB HEAD: Adrian B. Hehl

PROVIDER: PXD004583 | Pride | 2016-11-15

REPOSITORIES: Pride

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20130507_03_4754_Tom40_1_130508094122 (F238799).mzid_20130507_03_4754_Tom40_1_130508094122_(F238799).pride.mgf.gz Mzid
20130507_03_4754_Tom40_1_130508094122 (F238799).pride.mztab.gz Mztab
20130507_03_4754_Tom40_1_130508094122.RAW Raw
20130507_03_4754_Tom40_1_130508094122F238799.mzid.gz Mzid
20130507_03_4754_Tom40_1_130508094122F238799.mzid_20130507_03_4754_Tom40_1_130508094122_F238799.MGF Mzid
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Publications

An Interactome-Centered Protein Discovery Approach Reveals Novel Components Involved in Mitosome Function and Homeostasis in Giardia lamblia.

Rout Samuel S   Zumthor Jon Paulin JP   Schraner Elisabeth M EM   Faso Carmen C   Hehl Adrian B AB  

PLoS pathogens 20161207 12

Protozoan parasites of the genus Giardia are highly prevalent globally, and infect a wide range of vertebrate hosts including humans, with proliferation and pathology restricted to the small intestine. This narrow ecological specialization entailed extensive structural and functional adaptations during host-parasite co-evolution. An example is the streamlined mitosomal proteome with iron-sulphur protein maturation as the only biochemical pathway clearly associated with this organelle. Here, we a  ...[more]

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