Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion ETD
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): T Cell, Blood
SUBMITTER: Maartje van den Biggelaar
LAB HEAD: Maartje van den Biggelaar
PROVIDER: PXD004637 | Pride | 2017-05-02
REPOSITORIES: Pride
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van Aalderen Michiel C MC van den Biggelaar Maartje M Remmerswaal Ester B M EBM van Alphen Floris P J FPJ Meijer Alexander B AB Ten Berge Ineke J M IJM van Lier René A W RAW
Cell reports 20170501 5
Pathogens trigger T cells to express distinct sets of effector proteins. To better understand the molecular mechanisms that drive functional specification, we used high-resolution mass spectrometry and label-free protein quantification to measure proteomic differences between the seven largest circulating human CD8<sup>+</sup> T cell subsets. Hierarchical clustering of the proteomes placed naive and CD45RA-expressing effector-type T cells at the extremes of the spectrum, with central memory and ...[more]