Proteomics

Dataset Information

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Human WW-domain containing proteins TAP-LC-MSMS

ABSTRACT: To systematically investigate the regulations and functions of human WW-domain containing proteins, we conducted a proteomic analysis of 26 full-length WW-domain containing proteins and 17 WW-domains only, and identified their associated protein complexes in human HEK293T cells using tandem affinity purifications followed by LC-MSMS.

INSTRUMENT(S): LTQ

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Permanent Cell Line Cell, Cell Culture

DISEASE(S): Disease Free

SUBMITTER: Xu Li  

LAB HEAD: Junjie Chen

PROVIDER: PXD004649 | Pride | 2019-12-02

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
23100.RAW Raw
23100.mzid-pride.pride.mgf.gz Mzid
23100.mzid-pride.xml.gz Mzid
23100.mzid_23100.MGF Mzid
23101.RAW Raw
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Publications

Elucidation of WW domain ligand binding specificities in the Hippo pathway reveals STXBP4 as YAP inhibitor.

Vargas Rebecca E RE   Duong Vy Thuy VT   Han Han H   Ta Albert Paul AP   Chen Yuxuan Y   Zhao Shiji S   Yang Bing B   Seo Gayoung G   Chuc Kimberly K   Oh Sunwoo S   El Ali Amal A   Razorenova Olga V OV   Chen Junjie J   Luo Ray R   Li Xu X   Wang Wenqi W  

The EMBO journal 20191129 1

The Hippo pathway, which plays a critical role in organ size control and cancer, features numerous WW domain-based protein-protein interactions. However, ~100 WW domains and 2,000 PY motif-containing peptide ligands are found in the human proteome, raising a "WW-PY" binding specificity issue in the Hippo pathway. In this study, we have established the WW domain binding specificity for Hippo pathway components and uncovered a unique amino acid sequence required for it. By using this criterion, we  ...[more]

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