Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos, LTQ Orbitrap XL
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Inner Medullary Collecting Duct
DISEASE(S): Disease Free
SUBMITTER: Janos Demeter
LAB HEAD: Peter K. Jackson
PROVIDER: PXD004741 | Pride | 2016-08-15
REPOSITORIES: Pride
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Nature genetics 20160509 6
Cilia use microtubule-based intraflagellar transport (IFT) to organize intercellular signaling. Ciliopathies are a spectrum of human diseases resulting from defects in cilia structure or function. The mechanisms regulating the assembly of ciliary multiprotein complexes and the transport of these complexes to the base of cilia remain largely unknown. Combining proteomics, in vivo imaging and genetic analysis of proteins linked to planar cell polarity (Inturned, Fuzzy and Wdpcp), we identified and ...[more]