Proteomics

Dataset Information

0

Brown bear skeletal muscle quantitative LC-MSMS


ABSTRACT: Muscle atrophy is one of the main deleterious consequences of ageing and physical inactivity. Although basic knowledge regarding the underlying mechanisms of muscle atrophy is continuously growing, there are still no efficient therapeutic strategies for its prevention and treatment. Hibernating bears exhibit a strong and unique ability to preserve muscle mass in conditions where muscle atrophy is observed in humans. However, underlying mechanisms have not been understood yet. To fill this gap, the aim of this study was to characterize changes in the bear muscle proteome during hibernation versus the active period. Muscle biopsies were obtained from Ursus arctos bears.

INSTRUMENT(S): maXis 4G

ORGANISM(S): Ursus Arctos (brown Bear) (grizzly Bear)

TISSUE(S): Skeletal Muscle

SUBMITTER: Fabrice BERTILE  

LAB HEAD: Sarah Cianférani

PROVIDER: PXD004908 | Pride | 2019-05-14

REPOSITORIES: pride

Dataset's files

Source:
Action DRS
Results_MQ.zip Other
X21638AZ.d.zip Other
X21640AZ.d.zip Other
X21641AZ.d.zip Other
X21642AZ.d.zip Other
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Publications


<h4>Background</h4>In mammals, the hibernating state is characterized by biochemical adjustments, which include metabolic rate depression and a shift in the primary fuel oxidized from carbohydrates to lipids. A number of studies of hibernating species report an upregulation of the levels and/or activity of lipid oxidizing enzymes in muscles during torpor, with a concomitant downregulation for glycolytic enzymes. However, other studies provide contrasting data about the regulation of fuel utiliza  ...[more]

Publication: 1/2

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