Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Permanent Cell Line Cell, Cell Culture
SUBMITTER: Ivo Hendriks
LAB HEAD: Michael Lund Nielsen
PROVIDER: PXD004927 | Pride | 2017-01-24
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
HUMAN.fasta | Fasta | |||
MaxQuantOutput.tar.gz | Other | |||
QE6_LC6_IAH_SUMO_HeLa_1_All.raw | Raw | |||
QE6_LC6_IAH_SUMO_HeLa_1_F1.raw | Raw | |||
QE6_LC6_IAH_SUMO_HeLa_1_F2.raw | Raw |
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Nature structural & molecular biology 20170123 3
Small ubiquitin-like modifiers (SUMOs) are post-translational modifications (PTMs) that regulate nuclear cellular processes. Here we used an augmented K0-SUMO proteomics strategy to identify 40,765 SUMO acceptor sites and quantify their fractional contribution for 6,747 human proteins. Structural-predictive analyses revealed that lysines residing in disordered regions are preferentially targeted by SUMO, in notable contrast to other widespread lysine modifications. In our data set, we identified ...[more]