Dataset Information
Proteome analysis of Jurkat cells for spectral library
Ontology highlight
ABSTRACT:
INSTRUMENT(S): TripleTOF 6600
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Suspension Culture, Permanent Cell Line Cell
SUBMITTER: 
Andreas Schmidt
LAB HEAD: Axel Imhof
PROVIDER: PXD005111 | Pride | 2019-02-25
REPOSITORIES: Pride
Dataset's files
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Publications
Multi-Reference Spectral Library Yields Almost Complete Coverage of Heterogeneous LC-MS/MS Data Sets.
Journal of proteome research 20190308 4
Spectral libraries play a central role in the analysis of data-independent-acquisition (DIA) proteomics experiments. A main assumption in current spectral library tools is that a single characteristic intensity pattern (CIP) suffices to describe the fragmentation of a peptide in a particular charge state (peptide charge pair). However, we find that this is often not the case. We carry out a systematic evaluation of spectral variability over public repositories and in-house data sets. We show tha ...[more]
