Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Brain Gray Matter, Brain, Brain White Matter
DISEASE(S): Alzheimer's Disease
SUBMITTER: Norelle Wildburger
LAB HEAD: David Brody
PROVIDER: PXD005119 | Pride | 2017-09-04
REPOSITORIES: Pride
Items per page: 1 - 5 of 69 |
Scientific reports 20170825 1
Amyloid-beta (Aβ) plays a key role in the pathogenesis of Alzheimer's disease (AD), but little is known about the proteoforms present in AD brain. We used high-resolution mass spectrometry to analyze intact Aβ from soluble aggregates and insoluble material in brains of six cases with severe dementia and pathologically confirmed AD. The soluble aggregates are especially relevant because they are believed to be the most toxic form of Aβ. We found a diversity of Aβ peptides, with 26 unique proteofo ...[more]