Dataset Information

Determination of pancreatic cyst fluids peptidome and proteome

ABSTRACT: Determination of pancreatic cyst fluids (PCF) peptidome and proteome in 5 distinct patient groups: malignant (CAs), intraductal papillary mucinous neoplasms (IPMNs), mucinous cystic neoplasms (MCNs), serous cystic neoplasms (SCNs), and pseudocysts (PCs). The PCF <5kDa fraction, referred as the degradome, and proteome profiles were determined using a LTQ-Orbitrap Elite mass spectrometer coupled with a nanoAcquity LC system. Qualitative LC-MS/MS analyses were ran on pooled samples from all patients.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Tymon Rubel

LAB HEAD: Jerzy Ostrowski

PROVIDER: PXD005248 | Pride | 2019-01-14

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	CA_A_51124_kuba_5_can_A_300.dat-pride.pride.mgf.gz	Mgf
	CA_A_51124_kuba_5_can_A_300.dat-pride.pride.mztab.gz	Mztab
	CA_A_51124_kuba_5_can_A_300.dat-pride.xml.gz	Xml
	CA_A_51124_kuba_5_can_A_300.dat.gz	Other
	CA_A_51124_kuba_5_can_A_300.raw.gz	Raw

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Publications

Mass Spectrometry-Based Comprehensive Analysis of Pancreatic Cyst Fluids.

Paziewska Agnieszka A Polkowski Marcin M Rubel Tymon T Karczmarski Jakub J Wiechowska-Kozlowska Anna A Dabrowska Michalina M Mikula Michal M Dadlez Michal M Ostrowski Jerzy J Ostrowski Jerzy J

BioMed research international 20181129

Pancreatic cyst fluids (PCFs) enriched in tumour-derived proteins are considered a potential source of new biomarkers. This study aimed to determine compositional and quantitative differences between the degradome and proteome of PCFs aspirated from different types of pancreatic cyst lesions (PCLs). 91 patients who underwent endoscopic ultrasound-fine needle aspiration under routine clinical diagnosis of PCLs were enrolled. Four cysts were malignant (CAs), and 87 were nonmalignant and consisted ...[more]

PMID: 30627566

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