Proteomics

Dataset Information

0

Draft of the mitochondrial landscape, OM/IM


ABSTRACT: The mitochondrial subcompartment proteomes revealed by quantitative MS.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast)

TISSUE(S): Cell Culture

SUBMITTER: René Zahedi  

LAB HEAD: René Zahedi

PROVIDER: PXD005463 | Pride | 2017-08-24

REPOSITORIES: Pride

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Publications


The mitochondrial proteome comprises ~1000 (yeast)-1500 (human) different proteins, which are distributed into four different subcompartments. The sublocalization of these proteins within the organelle in most cases remains poorly defined. Here we describe an integrated approach combining stable isotope labeling, various protein enrichment and extraction strategies and quantitative mass spectrometry to produce a quantitative map of submitochondrial protein distribution in S. cerevisiae. This qua  ...[more]

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