Proteomics

Dataset Information

0

THE ATHEROMA PLAQUE SECRETOME STIMULATES THE MOBILIZATION OF ENDOTHELIAL PROGENITOR CELLS EX VIVO


ABSTRACT: in this study we evaluated the initial response promoted by the atherosclerotic plaque (AP) secreted factors over healthy endothelial progenitor cells (EPCs), in order to understand the mechanisms underlying the neovascularization and vascular remodeling properties assigned to these cells and to use them as cell therapy in cardiovascular diseases.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture, Endothelial Cell

SUBMITTER: Maarten Altelaar  

LAB HEAD: Maarten Altelaar

PROVIDER: PXD005465 | Pride | 2018-10-02

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
OR11_20150710_VMG_M3EPC_273_C.msf Msf
OR11_20150710_VMG_M3EPC_273_C.raw Raw
OR11_20150710_VMG_M3EPC_274_C.msf Msf
OR11_20150710_VMG_M3EPC_274_C.raw Raw
OR11_20150710_VMG_M3EPC_275_C.msf Msf
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Publications


Endothelial progenitor cells (EPCs) constitute a promising alternative in cardiovascular regenerative medicine due to their assigned role in angiogenesis and vascular repair. In response to injury, EPCs promote vascular remodeling by replacement of damaged endothelial cells and/or by secreting angiogenic factors over the damaged tissue. Nevertheless, such mechanisms need to be further characterized. In the current approach we have evaluated the initial response of early EPCs (eEPCs) from healthy  ...[more]

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