Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Fibroblast
SUBMITTER: Vesela Encheva
LAB HEAD: Ambrosius Snijders
PROVIDER: PXD005717 | Pride | 2017-03-09
REPOSITORIES: Pride
Items per page: 1 - 5 of 33 |
Cell reports 20170301 10
Cellular senescence is an important in vivo mechanism that prevents the propagation of damaged cells. However, the precise mechanisms regulating senescence are not well characterized. Here, we find that ITGB3 (integrin beta 3 or β3) is regulated by the Polycomb protein CBX7. β3 expression accelerates the onset of senescence in human primary fibroblasts by activating the transforming growth factor β (TGF-β) pathway in a cell-autonomous and non-cell-autonomous manner. β3 levels are dynamically inc ...[more]