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Proteomic and phosphoproteomic changes in C.elegans embryo as a result of pig-1 mutation

ABSTRACT: Comparison of the proteome and phosphoproteome of wild type C.elegans embryos compared to pig-1 mutant embryos

INSTRUMENT(S): Q Exactive

ORGANISM(S): Caenorhabditis Elegans

TISSUE(S): Embryo

SUBMITTER: Dalila Bensaddek

LAB HEAD: Anton Gartner

PROVIDER: PXD005752 | Pride | 2017-12-11

REPOSITORIES: Pride

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Publications

Comparative genetic, proteomic and phosphoproteomic analysis of C. elegans embryos with a focus on ham-1/STOX and pig-1/MELK in dopaminergic neuron development.

Offenburger Sarah-Lena SL Bensaddek Dalila D Murillo Alejandro Brenes AB Lamond Angus I AI Gartner Anton A

Scientific reports 20170628 1

Asymmetric cell divisions are required for cellular diversity and defects can lead to altered daughter cell fates and numbers. In a genetic screen for C. elegans mutants with defects in dopaminergic head neuron specification or differentiation, we isolated a new allele of the transcription factor HAM-1 [HSN (Hermaphrodite-Specific Neurons) Abnormal Migration]. Loss of both HAM-1 and its target, the kinase PIG-1 [PAR-1(I)-like Gene], leads to abnormal dopaminergic head neuron numbers. We identifi ...[more]

PMID: 28659600

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