Proteomics

Dataset Information

0

Quantification of the GDNF-regulated proteome and phosphoproteome in spermatogonial progenitor cells (SPCs)


ABSTRACT: A quantitative mass-spectrometry-based proteome and phosphoproteome profiles of SPCs following sustained stimulation with glial cell-derived neurotrophic factor (GDNF).

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Cell Culture

SUBMITTER: hao zhang  

LAB HEAD: Xuejiang Guo

PROVIDER: PXD005756 | Pride | 2017-04-20

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
SSC-TMT6-150ug-HP-RP.zip Other
SSC-TMT6-HP-RP-1-20131109.raw Raw
SSC-TMT6-HP-RP-10-20131109.raw Raw
SSC-TMT6-HP-RP-11-20131109.raw Raw
SSC-TMT6-HP-RP-12-20131109.raw Raw
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Publications

The Glial Cell-Derived Neurotrophic Factor (GDNF)-responsive Phosphoprotein Landscape Identifies Raptor Phosphorylation Required for Spermatogonial Progenitor Cell Proliferation.

Wang Min M   Guo Yueshuai Y   Wang Mei M   Zhou Tao T   Xue Yuanyuan Y   Du Guihua G   Wei Xiang X   Wang Jing J   Qi Lin L   Zhang Hao H   Li Lufan L   Ye Lan L   Guo Xuejiang X   Wu Xin X  

Molecular & cellular proteomics : MCP 20170413 6


Cytokine-dependent renewal of stem cells is a fundamental requisite for tissue homeostasis and regeneration. Spermatogonial progenitor cells (SPCs) including stem cells support life-long spermatogenesis and male fertility, but pivotal phosphorylation events that regulate fate decisions in SPCs remain unresolved. Here, we described a quantitative mass-spectrometry-based proteomic and phosphoproteomic analyses of SPCs following sustained stimulation with glial cell-derived neurotrophic factor (GDN  ...[more]

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