Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Cell Culture, Fibroblast
SUBMITTER: Tanveer Batth
LAB HEAD: Jesper Velgaard Olsen
PROVIDER: PXD005803 | Pride | 2018-03-07
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
MaxQuant-PDGF-SHP099-SILAC.zip | Other | |||
Phospho-MQ-output.zip | Other | |||
RTKPhospho.zip | Other | |||
SILAC-pSTY-SHP099-rawfiles.zip | Other | |||
tables.pdf |
Items per page: 1 - 5 of 5 |
Cell reports 20180301 10
Despite its low cellular abundance, phosphotyrosine (pTyr) regulates numerous cell signaling pathways in health and disease. We applied comprehensive phosphoproteomics to unravel differential regulators of receptor tyrosine kinase (RTK)-initiated signaling networks upon activation by Pdgf-ββ, Fgf-2, or Igf-1 and identified more than 40,000 phosphorylation sites, including many phosphotyrosine sites without additional enrichment. The analysis revealed RTK-specific regulation of hundreds of pTyr s ...[more]