Proteomics

Dataset Information

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Multi-omics Analysis of Salmonella enterica Serovar Typhimurium Infection of Wild Type C57BL/6 and Immunodeficient gp91-/-phox Mice


ABSTRACT: Three groups of sex- and aged-matched 9-12 week old C57BL/6 wild type mice and gp91-/-phox mice were infected by i.v. injection of bacterial suspensions: Group 1 represents wild type C57BL/6 mice infected with virulent S. Typhimurium SL1344 grown in vitro. (Raw files: OTNCS_AGSL1344#3C#9C#10C-XX) Group 2 represents wild type C57BL/6 mice infected with virulent S. Typhimurium SL1344 grown in vivo for 72 h in the Group 1 C57BL/6 mice. (Raw files: OTNCS_AGSL1344#9F#10F-XX) Group 3 represents immunodeficient gp91-/-phox mice infected with virulent S. Typhimurium SL1344 grown in vitro. (Raw files: OTNCS_AGSL1344#11C#12C#13C-XX) And Input (Raw files: OTNCS_AGSL1344mixedAa-XX and OTNCS_AGSL1344mixedAb-XX)

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Salmonella Enterica Subsp. Enterica Serovar Typhimurium Str. Sl1344

SUBMITTER: James Wright  

LAB HEAD: Jyoti Choudhary

PROVIDER: PXD005855 | Pride | 2018-10-26

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
F021744.mgf Mgf
F021744.mzid Mzid
F021746.mgf Mgf
F021746.mzid Mzid
F021747.mgf Mgf
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Publications

Transcriptome and proteome analysis of Salmonella enterica serovar Typhimurium systemic infection of wild type and immune-deficient mice.

Oshota Olusegun O   Conway Max M   Fookes Maria M   Schreiber Fernanda F   Chaudhuri Roy R RR   Yu Lu L   Morgan Fiona J E FJE   Clare Simon S   Choudhary Jyoti J   Thomson Nicholas R NR   Lio Pietro P   Maskell Duncan J DJ   Mastroeni Pietro P   Grant Andrew J AJ  

PloS one 20170810 8


Salmonella enterica are a threat to public health. Current vaccines are not fully effective. The ability to grow in infected tissues within phagocytes is required for S. enterica virulence in systemic disease. As the infection progresses the bacteria are exposed to a complex host immune response. Consequently, in order to continue growing in the tissues, S. enterica requires the coordinated regulation of fitness genes. Bacterial gene regulation has so far been investigated largely using exposure  ...[more]

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