Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA373859
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Hek-293t Cell
SUBMITTER: Eric Fischer
LAB HEAD: Eric Sebastian Fischer
PROVIDER: PXD005857 | Pride | 2017-05-29
REPOSITORIES: Pride
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140425_psilac_t6_1dmso_s01.raw | Raw | |||
140425_psilac_t6_1dmso_s02.raw | Raw | |||
140425_psilac_t6_1dmso_s03.raw | Raw | |||
140425_psilac_t6_1dmso_s04.raw | Raw | |||
140425_psilac_t6_1dmso_s05.raw | Raw |
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Nature communications 20170522
Thalidomide and its derivatives lenalidomide and pomalidomide (IMiDs) are effective treatments of haematologic malignancies. It was shown that IMiDs impart gain-of-function properties to the CUL4-RBX1-DDB1-CRBN (CRL4<sup>CRBN</sup>) ubiquitin ligase that enable binding, ubiquitination and degradation of key therapeutic targets such as IKZF1, IKZF3 and CSNK1A1. While these substrates have been implicated as efficacy targets in multiple myeloma (MM) and 5q deletion associated myelodysplastic syndr ...[more]