Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Breast Epithelium, Cell Culture
DISEASE(S): Breast Cancer
SUBMITTER: Evgenia Shishkova
LAB HEAD: Joshua J Coon
PROVIDER: PXD005871 | Pride | 2017-07-03
REPOSITORIES: Pride
Items per page: 5 1 - 5 of 54 |
Shishkova Evgenia E Zeng Hao H Liu Fabao F Kwiecien Nicholas W NW Hebert Alexander S AS Coon Joshua J JJ Xu Wei W
Nature communications 20170524
Protein arginine methyltransferases (PRMTs) introduce arginine methylation, a post-translational modification with the increasingly eminent role in normal physiology and disease. PRMT4 or coactivator-associated arginine methyltransferase 1 (CARM1) is a propitious target for cancer therapy; however, few CARM1 substrates are known, and its mechanism of substrate recognition is poorly understood. Here we employed a quantitative mass spectrometry approach to globally profile CARM1 substrates in brea ...[more]