Dataset Information

Mass spectrometry identification of Trypanosoma brucei bloodstream form proteins that interacts with Ins(1,4,5)P3 and Ins(1,3,4,5)P4.

ABSTRACT: Mass spectrometry identification of Trypanosoma brucei bloodstream form proteins that interacts with Ins(1,4,5)P3 and Ins(1,3,4,5)P4.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Trypanosoma Brucei

TISSUE(S): Primary Cell Line Cell

DISEASE(S): Trypanosomiasis

SUBMITTER: Atashi Anupama

LAB HEAD: Dr. Kenneth D. Stuart

PROVIDER: PXD005907 | Pride | 2018-10-26

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	IC072312_072612_S1.RAW	Raw
	IC072312_072612_S2.RAW	Raw
	IC072312_072612_S3.RAW	Raw
	IC080415_081015_IP3_AP_Eluate_2.raw	Raw
	IC080415_081015_IP4_AP_Eluate_2.raw	Raw

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Publications

Inositol polyphosphate multikinase regulation of Trypanosoma brucei life stage development.

Cestari Igor I Anupama Atashi A Stuart Kenneth K

Molecular biology of the cell 20180322 9

Many cellular processes change during the Trypanosoma brucei life cycle as this parasite alternates between the mammalian host and tsetse fly vector. We show that the inositol phosphate pathway helps regulate these developmental changes. Knockdown of inositol polyphosphate multikinase (IPMK), which phosphorylates Ins(1,4,5)P3 and Ins(1,3,4,5)P4, resulted in changes in bloodstream forms that are characteristic of insect stage procyclic forms. These changes include expression of the procyclic surf ...[more]

PMID: 29514930

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