Dataset Information

Proteomic analysis of the ciliary 5HT6 Interactome

ABSTRACT: We analyzed the interaction of a ciliary targeted 5HT6.APEX.GFP fusion protein

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Markus Rinschen

LAB HEAD: Markus Rinschen

PROVIDER: PXD005926 | Pride | 2017-07-18

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	20150513_HN_PryankaKohli_Ag_Benzing_Flp_Apex_IN_NIH_S_01.index	Other
	20150513_HN_PryankaKohli_Ag_Benzing_Flp_Apex_IN_NIH_S_01.raw	Raw
	20150513_HN_PryankaKohli_Ag_Benzing_Flp_Apex_IN_NIH_S_02.index	Other
	20150513_HN_PryankaKohli_Ag_Benzing_Flp_Apex_IN_NIH_S_02.raw	Raw
	20150513_HN_PryankaKohli_Ag_Benzing_Flp_Apex_IN_NIH_S_03.index	Other

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Publications

The ciliary membrane-associated proteome reveals actin-binding proteins as key components of cilia.

Kohli Priyanka P Höhne Martin M Jüngst Christian C Bertsch Sabine S Ebert Lena K LK Schauss Astrid C AC Benzing Thomas T Rinschen Markus M MM Schermer Bernhard B

EMBO reports 20170714 9

Primary cilia are sensory, antennae-like organelles present on the surface of many cell types. They have been involved in a variety of diseases collectively termed ciliopathies. As cilia are essential regulators of cell signaling, the composition of the ciliary membrane needs to be strictly regulated. To understand regulatory processes at the ciliary membrane, we report the targeting of a genetically engineered enzyme specifically to the ciliary membrane to allow biotinylation and identification ...[more]

PMID: 28710093

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