Dataset Information

Plasma Proteome profiles of stable CAD patients stratified according to total Apo CIII levels

ABSTRACT: Apolipoprotein C-III was recently acknowledged as a prognostic marker for cardiovascular risk. High levels of Apo-CIII strongly correlate with hypertriglyceridemia and are associated with atherosclerosis and coronary heart disease (CAD). Aim of the present research was to study the plasma proteome profiles of stable CAD patients characterized by different levels of total Apo-CIII. Two subgroups of CAD patients with divergent concentrations (under and upper the median concentration of the population distribution=10mg/dL) of total circulating Apo C-III were examined using a shotgun proteomic approach. 180 plasma proteins of CAD patients were quantified and the data were analyzed by bioinformatic tools and multivariate statistics. The fold change analysis and the Partial Least Square Discriminant Analysis showed a clear separation of the two groups. The dynamic processes that involve Apo C-III concentration in blood and its relation with all other plasma proteins were considered. Lipoproteins (Apo C-II and Apo E), retinol-binding protein 4 and vitronectin were up-regulated in patients with high Apo C-III, while alpha 1-antitrypsin was down-regulated. In this pilot study, the different expression of plasma proteins through the entire range of concentrations of Apo C-III was defined, suggesting possible new players involved in the APO C-III-associated process of arterial damage

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

SUBMITTER: Marcello Manfredi

LAB HEAD: Marcello Manfredi

PROVIDER: PXD005973 | Pride | 2018-07-05

REPOSITORIES: Pride

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Plasma Proteome Profiles of Stable CAD Patients Stratified According to Total Apo C-III Levels.

Manfredi Marcello M Chiariello Carmela C Conte Eleonora E Castagna Annalisa A Robotti Elisa E Gosetti Fabio F Patrone Mauro M Martinelli Nicola N Bassi Antonella A Cecconi Daniela D Marengo Emilio E Olivieri Oliviero O

Proteomics. Clinical applications 20180807 3

<h4>Purpose</h4>The present research reports the study the of plasma proteome profile of stable coronary artery disease (CAD) patients characterized by different levels of total Apolipoprotein-CIII (Apo C-III), a prognostic marker for cardiovascular risk.<h4>Experimental design</h4>Two subgroups of CAD patients (n = 52) with divergent concentrations of total circulating Apo C-III (≤ and ≥10 mg dL<sup>-1</sup> ) are examined using a shotgun proteomic approach. Validation experiments are also perf ...[more]

PMID: 29992792

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			Action	DRS
	APOC3DDAMS.dat	Other
	APOC3DIAMS.dat	Other
	APOC3DIAtotPP.group	Other
	APO_1-25.group	Other
	APO_26-55.group	Other