Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Cricetulus Griseus (chinese Hamster) (cricetulus Barabensis Griseus)
SUBMITTER: David Plotnik
LAB HEAD: Shiu-Lok Hu
PROVIDER: PXD006062 | Pride | 2017-09-04
REPOSITORIES: Pride
Plotnik David D Guo Wenjin W Cleveland Brad B von Haller Priska P Eng Jimmy K JK Guttman Miklos M Lee Kelly K KK Arthos James J Hu Shiu-Lok SL
Journal of virology 20171013 21
Gut-homing α<sub>4</sub>β<sub>7</sub><sup>high</sup> CD4<sup>+</sup> T lymphocytes have been shown to be preferentially targeted by human immunodeficiency virus type 1 (HIV-1) and are implicated in HIV-1 pathogenesis. Previous studies demonstrated that HIV-1 envelope protein gp120 binds and signals through α<sub>4</sub>β<sub>7</sub> and that this likely contributes to the infection of α<sub>4</sub>β<sub>7</sub><sup>high</sup> T cells and promotes cell-to-cell virus transmission. Structures withi ...[more]