Dataset Information
Mouse Stereocilia Capping Protein Immunoaffinity Purification
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion ETD
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Inner Ear Vestibulum, Ear Hair Cell, Cochlea, Auditory Hair Cell, Inner Ear, Vestibular Hair Cell
SUBMITTER: 
Peter Barr-Gillespie
LAB HEAD: Peter Barr-Gillespie
PROVIDER: PXD006077 | Pride | 2017-08-25
REPOSITORIES: Pride
Dataset's files
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Publications
Heterodimeric capping protein is required for stereocilia length and width regulation.
The Journal of cell biology 20170912 11
Control of the dimensions of actin-rich processes like filopodia, lamellipodia, microvilli, and stereocilia requires the coordinated activity of many proteins. Each of these actin structures relies on heterodimeric capping protein (CAPZ), which blocks actin polymerization at barbed ends. Because dimension control of the inner ear's stereocilia is particularly precise, we studied the CAPZB subunit in hair cells. CAPZB, present at ∼100 copies per stereocilium, concentrated at stereocilia tips as h ...[more]
